ho·ly (adjective)
  1. Belonging to, derived from, or associated with a divine power;
  2. Regarded with or worthy of worship or veneration;

http://dictionary.reference.com/search?q=holy

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Men are notorious for wearing underwear way past their usefulness.  I have a pair that I only wear on Sundays…They are holy! (rim-shot please!)

Seriously…

God is holy in His absolute uniqueness. Everything else belongs to a class. We are human. Rover is a dog, the oak is a tree. Earth is a planet, the Milky Way is one of a million galaxies, Gabriel is an angel, Satan is a demon. But only God is God. And therefore He is holy, utterly different, distinct, unique.

All else is creation. He alone creates. All else begins. He alone always was. All else depends. He alone is self-sufficient.

And therefore the holiness of God is synonymous with His infinite value. Diamonds are valuable because they are rare and hard to make. God is infinitely valuable because He is the rarest of all beings and cannot be made at all, nor was He ever made. If I were a collector of rare treasures and could somehow have God, the Holy One, in my treasury, I would be wealthier than all the collectors of all the rarest treasures that have ever lived.

The holiness of God is the absolutely unique infinite value of His majestic glory. To say that our God is holy means that He is beautiful beyond degree in the magnificence of His glory and that His value is infinitely greater than the sum of the value of all created beings.

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Reflect on these words:

Holy, holy, holy, Lord God Almighty
Early in the morning our song shall rise to Thee
Holy, holy, holy, merciful and mighty
God in three persons, blessed Trinity

Holy, holy, holy, all the saints adore Thee
Casting down their golden crowns around the glassy sea
Cherubim and seraphim, falling down before Thee
Which, wert and art and ever more shall be

Holy, holy, holy, though the darkness hide Thee
Though the eye of sinful men Thy Glory may not see
Only Thou art holy, there is none beside Thee
Perfect in power, in love and purity

Holy, holy, holy, Lord God Almighty
All Thy works shall praise Thy Name in earth and sky and sea
Holy, holy, holy, merciful and mighty
God in three persons, blessed Trinity